Anti-diabetic Effect of Sprouted Trigonella foenumgraecum L. Seed Solid Dosage Form in Low-dose Streptozotocin Induced Diabetic Rats

Abstract: Background: Trigonella foenum-graecum L (Fenugreek) is an annual herb, mainly cultivated for its seed as well sprouts. Pharmacological investigations reported anti-bacterial, anti-diabetic, anti-cancer, anti-diarrheal, anti-hypercholesteremic, and antiinflammatory activities of L. Aim: The purpose this study was to accentuate on formulation granules investigate the effect germinated (TFG) in Diabetes mellitus (DM) rats induced by streptozotocin fenugreek retains hypoglycemic property. Materials Methods: Granules TFG powder were arranged means several excipients comprising diverse amounts super disintegrants (wet) granulation method proceed solid dosage form evaluation. Further, in-vivo performed STZ DM Wister four weeks. 1600mg/kg Glibenclamide 0.45 mg/kg (as a positive control comparison) orally administrated evaluate diabetics rats. Results: All evaluation parameters are correct: standard tablet. (Streptozotocin) treatment with Drug (Glibenclamide) significantly lowered blood plasma glucose levels 36% (mean ± SD 120 0.6 mg/dL (p < 0.001)) 38% 114 0.4 mg/dL; p 0.001) respectively after 4 weeks when compared T2DM (Type 2 mellitus) Conclusion: Experimental studies had shown that bioactive compounds found Foenum graceum herb have potential cure diabetes especially due presence unique chemical constituent including trigonelline, galactomannan amino acid 4-hydroxy isoleucine. These findings suggested may be alternative medicine management DM. Keywords: foenum-graecum, Fenugreek, Anti-diabetic, Tablet, mellitus.